Here is a real world example for you. My core has 3 PVR150 cards in it. 2 of them go to satellite receivers, one of them goes to a Roku Netflix Player box. I also have media stored on the various hard drives attached to the core, as well as a DVD drive.
In this scenario, I was using 4 MD's and the core hybrid MD.
Core/Hybrid was watching a satellite feed from MythTV.
MD 1 was watching a DVD placed in the Core/Hybrids DVD drive
MD 2 was watching the Netflix Player Feed
MD 3 was watching a video playlist stored on the Core/Hybrid
MD 4 was watching a recording in progress from tuner 2 on the satellite box
My network is Gigabit, with a Gigabit feed from the core. MD 1 was also connected Gigabit, MD 2, 3 and 4 are connected 100Mbit.
It can be done, Using the media map, I could have easily taken the DVD stream, or the Video stream, or the Netflix stream, and sent it to all or 1 or 2....
So the answer is Yes it can be done.
Isn't this the most powerful media platform ever??
Regards,
Seth