Please give us more information to help you out.
Whate is your core running (i386 or amd64) and what is your media directors running, and exactly what is the issue that you are having.
In my case my core is i386 and it autodetects my media director to am64. I manually had to change the media director to i386 due to issues with my nic card driver (marvell yukon.)
I installed the amd64 version on the hybrid which is an intel core 2 duo 6400. The 1st MD is an intel P4 3Mhz and the second MD is an AMD athlon 64 2x 4200. I have several issues:
1. The AMD MD has netboot problems....during several installations, sometimes it would boot and other not at all, which is the case now.
2. Video playback freezing on all computers.
3. Ripping a DVD on the hybrid loads down the computer until it is complete. This has never happened before. I could rip a dvd, record a video in mythtv and watch another with no problem.
I read jondecker76's post on the 17th and it seemed like a possible solution.